Before using cefoperazone, inform your doctor about your current list of medications, over the counter products e. Serum cefoperazone concentrations ranged from 109 to 159. Superiority of cefoperazonesulbactam also was demonstrated for this endpoint, with. Cefobid is a white powder which is freely soluble in water. List of approved drug products containing cefoperazone and sulbactam1 in the fda orange book on. In severe or refractory infections, the daily dosage of sulbactamcefoperazone may be. In severe or refractory infections, the daily dosage of sulbactamcefoperazone may be increased up to 8 g of the 1. Cefoperazonesulbactam sulperazon is a coformulation with sulbactam.
Cefoperazone and cefoperazonesulbactam johns hopkins. After 1 gram of cefoperazone given intravenously in 2 women, milk cefoperazone was 0. Cefoperazone sodium is a semisynthetic broadspectrum cephalosporin antibiotic and sulbactam sodium is a derivative of the basic penicillin. The usual adult dose of the combination is 2 to 4 gday i. If you experience drowsiness, dizziness, hypotension or a headache as sideeffects when using cefoperazone medicine then it may not be safe to drive a vehicle or operate heavy machinery. Listing a study does not mean it has been evaluated by the u. Cefoperazone and sulbactam c min were measured simultaneously in 103 plasma samples from 70 cirrhotic patients. Sulbactam cefoperazone is indicated for the treatment of the following infections when caused by suscept. After multiple dosage in rats of 50 mgkg bw during 7 days, 100% was recovered in urine and faeces at two days after the last dosage. Apr 20, 2007 cefoperazone sulbactam in the treatment of serious intraabdominal and hepatobiliary infections.
One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your bloodpressure extensively. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Cefoperazone sulbactam injection uses, sideeffects. For the treatment of gynecological infections due to susceptible, betalactamaseproducing strains of e coli, bacteroides species including b fragilis usual adult dose for endocarditis. For the treatment of skin and skin structure infections due to susceptible, betalactamaseproducing strains of staphylococcus aureus, escherichia coli, klebsiella species including k pneumoniae. The invention discloses a stable compound preparation of cefoperazonesulbactam drug, which is comprised by cefoperazone acid, sulbactam and latent solvent, which weight ratio is 81. Up to 4 g daily, given in equally divided doses every. Cefoperazonesulbactam in the treatment of serious intra. Dose levels used are 250 mg cefoperazone sodium per infected quarter once or 100 mg cefoperazone dihydrate per infected quarter twice with a dosing interval of.
Cefoperazonesulbactam in continuous infusion article pdf available in anestezjologia intensywna terapia 422. Cefoperazonesulbactam therapeutic drug monitoring in. You should not use this information on this web site or the information on links from this site to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. In serious or refractory infections, these dosages may be increased up to 240mgkgday 160 mgkgday cefoperazone activity. List of nationally authorised medic inal products ema7146292016 page 22 product name in authorisation country mrpdcp authorisation number national authorisation number mah of product in the.
Some health conditions may make you more susceptible to the sideeffects of the drug. Seventy hospitalized patients with upper urinary tract infections were treated with cefoperazone 2 gm and sulbactam 1 gm every 12 hours for three or more days. It was undetectable in milk 1 and 6 hours after the dose. Ratio sulbactam sulbactam cefoperazone cefoperazone activity activity g g g 1. Renal impairment dosage regimens of sulbactamcefoperazone should be adjusted in patients with a marked decrease in renal function.
Patients have been successfully treated with a total daily dosage of 612. Neonatal dose pediatric dose cefoperazone cefobid, cefazone 1gvial i. Clinical experience with cefoperazonesulbactam indicates that it is unlikely to impair a patients ability to drive or use machinery. Efficacy of this organism in this organ system was studied in fewer than 10 infections. Cn101036654b stable cefoperazone sulbactam medicine. In severe infections or infections caused by less sensitive organisms, the total daily dose andor frequency may be. May 10, 2018 cefoperazone sulbactam is an antibiotic medicine which comes in the form of a vial containing cefoperazone sodium equivalent to mg of cefoperazone and sulbactam sodium equivalent to 500 mg sulbactam.
We retrospectively analyzed the effect of tigecycline and cefoperazonesulbactam therapies on the. Antimicrobial activities of cefoperazone sulbactam in comparison to cefoperazone against clinical organisms from medical centers in taiwan tsungta chiang 1, hungjen tang 2, chenghsun chiu 3, teli chen 4, maowang ho 5, chenhsiang lee 6, wanghuei sheng 7, yasung yang 1. Find patient medical information for cefoperazone injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Cefoperazonesulbactam in the treatment of serious intraabdominal and hepatobiliary infections. Related substances of the compound preparation in the invention are lower than.
The usual adult daily dose of cefobid sterile cefoperazone is 2 to 4 grams per day administered in equally divided doses every 12 hours. Cefoperazone sbtcpz g sulbactam g cefoperazone g 1. Nov 16, 2007 dosage regimens of sulbactam cefoperazone should be adjusted in patients with marked decreased in renal function creatinine clearance of less than 20mlmin to compensate for the reduced clearance of sulbatam. Antimicrobial activities of cefoperazonesulbactam in comparison to cefoperazone against clinical organisms from medical centers in taiwan tsungta chiang 1, hungjen tang 2, chenghsun chiu 3, teli chen 4, maowang ho 5, chenhsiang lee 6, wanghuei sheng 7, yasung yang 1 1 department of internal medicine, national defense medical center, division of. Pdf cefoperazonesulbactam for treatment of intraabdominal. In severe infections or infections caused by less sensitive organisms, the total daily dose andor frequency may be increased. Ampicillin sulbactam dosage guide with precautions. Nine patients infected with strains with cefoperazonesulbactam mics of 4284 mgl and eight patients infected with strains with cefoperazonesulbactam mics of 168 mgl had a cefoperazonesulbactam therapeutic success rate of 66. Forty of the 70 patients 57% were cured of infection at one week after treatment, relapsed, 11 had reinfections, and six were lost. In severe or refractory infections the daily dosage of sulbactamcefoperazone may be increased up to 8 g of the 1. It is one of few cephalosporin antibiotics effective in treating pseudomonas bacterial infections which are otherwise resistant to these antibiotics. Cefoperazone is a thirdgeneration cephalosporin antibiotic, marketed by pfizer under the name cefobid. The ph of a 25% wv freshly reconstituted solution varies between 4.
Oct 31, 2017 cefobid sterile cefoperazone contains 34 mg sodium 1. Cefoperazone and cefoperazonesulbactam is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Cefoperazone should be used in enterococcal infections with care and at doses that achieve satisfactory serum levels of cefoperazone. Relevant published information was not found as of the revision date. Cefobid sterile cefoperazone in crystalline form is supplied in vials containing 1 g or 2 g cefoperazone as cefoperazone sodium for intravenous or intramuscular administration.
Dosage regimens of sulbactamcefoperazone should be adjusted in patients with marked decrease in renal function creatinine clearance of less than 30 mlmin to compensate for the reduced clearance. In severe or refractory infections, the daily dosage of sulbactam cefoperazone may be increased up to 8 g of the 1. The latent solvent is preferred selected from sodium carbonate and sodium bicarbonate. The protein binding of cefoperazone is 8293% and that of sulbactam is 38%. In the propensity score analysis with 17 casecontrol pairs, the success rate in the cefoperazonesulbactam group 70. Information provided on this web site is neither intended nor implied to be a substitute for professional medical advice.
In severe or refractory infections, the daily dosage of sulbactamcefoperazone may be increased up to 12 g of the 1. Parker sw, baxter j, beam tr cefoperazoneinduced coagulopathy. Cefoperazone was little metabolised in mouse, rat, rabbit, dog, monkey and man. Dosing information in renal impairment 5 14 cefuroxime sodium inj. Antimicrobial activities of cefoperazonesulbactam in.
An alternative to such combinations is the use of a beta lactam beta lactamase inhibitor combination. Daily dosage recommendations for sulbactamcefoperazone in adults are as follows. In addition, it demonstrates synergistic activity up to 4fold reduction in the minimum inhibitory concentrations for the combination versus those for each component in a. Cefoperazone and cefoperazonesulbactam johns hopkins abx guide. Doses should be administered every 12 hours in equally divided doses. Saito a, ueda y multicenter clinical trials of cefoperazone in japan. The dose is expressed as the total of ampicillin content plus sulbactam content in a constant 2. Cefoperazone sodium injectioncefobid generic is a cephalosporin antibiotic, prescribed for susceptible infections such as respiratory tract infection, infections of the skin and skin structures. In severe or refractory infections the daily dosage may be increased to 8g i. Before using cefoperazone sulbactam injection, inform your doctor about your current list of medications, over the counter products e. The recommended maximum daily dosage of sulbactam is 4 g. Cefoperazonesulbactam combination in the treatment of. Cefoperazone sulbactam is an antibiotic medicine which comes in the form of a vial containing cefoperazone sodium equivalent to mg of cefoperazone and sulbactam sodium equivalent to 500 mg sulbactam.
Use of cefoperazonesulbactam in neonates article pdf available in pediatrics international 541. After oral administration in rats about 9% was excreted by biliary, 2% by urinary route and about 96% was excreted with faeces. Comparison of tigecycline or cefoperazonesulbactam therapy. Neonates are at high risk for nosocomial infections due to multidrugresistant pathogens. Cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract. Dosage regimens of sulbactamcefoperazone should be adjusted in patients with marked decreased in renal function creatinine clearance of less than 20mlmin to compensate for the reduced clearance of sulbatam. Renal impairment dosage regimens of sulbactam cefoperazone should be adjusted in patients with a marked decrease in renal function. Comparison of empirical therapy with cefoperazonesulbactam.
The majority of adverse events are of mild or moderate severity and are tolerated with continued treatment. High serum and bile levels of cefobid are attained after a single dose of the drug. Comparison of tigecycline or cefoperazonesulbactam. Cefobid sterile cefoperazone contains 34 mg sodium 1. Pdf combinations of a thirdgeneration cephalosporin and metronidazole, with or without. Magnex cefoperazone sulbactam is one such combination, which has been shown to be as effective as a standard multidrug regimen such as gentamicin and clindamycin in the management of intraabdominal infections. No statistically significant differences in success rates or 14 day mortality were found between the cefoperazonesulbactam n 17 and carbapenem n 46 groups.
Pharmacodynamics modeling to optimize dosage regimens of. In severe or refractory infections, the daily dosage of sulbactam cefoperazone may be increased up to 12 g of the 1. List of approved drug products containing cefoperazone and sulbactam 1 in the fda orange book on. Cefoperazone and sulbactam1 fda orange book approved. Children the usual dosage in children is 4080mgkgday 20 to 40 mgkgday each of cefoperazone and sulbactam every six to twelve hours. Cefobid sterile cefoperazone in crystalline form is supplied in vials. Gardner wg multicentered clinical evaluation of cefoperazone for the treatment of lower respiratory tract infections. Parker sw, baxter j, beam tr cefoperazone induced coagulopathy.
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